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Advances in C-glycosylflavonoid Research

[ Vol. 16 , Issue. 7 ]


Oualid Oualid and Artur M. S. Silva   Pages 859 - 896 ( 38 )


C-glycosylflavonoids represent a group of oxygen heterocyclic compounds found widespread in a variety of plants. Synthetic organic chemists are now progressively utilizing C-glycosylflavonoid scaffolds due to their high biological potential. The present review deals with advances in C-glycosylflavonoids research, namely establishing a new updated database of the natural occurrence of Cglycosylflavonoids - one hundred and nine new structures have been reported up to 2011. The structural characterization of some novel C-glycosylflavonoids from various plant species is also discussed. The reported organic synthetic routes along with the biosynthetic aspects of C-glycosylflavonoids are also reviewed. Finally the paper underlines the wide range of C-glycosylflavonoid biological activity. The mentioned topics are detailed in particular chapters and are supported in 187 references.


Flavonoids, C-glycosylflavonoids, Mono-C-glycosylflavonoids, Di-C-glycosylflavonoids, O-glycosyl-C-glycosylflavonoids, Oacylated- C-glycosylflavonoids, Mass spectrometry, 1D and 2D NMR spectroscopy, Synthesis, Biosynthesis, Metabolism, Biological activity; Antioxidant activity.


Chemistry Department & QOPNA, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.

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