Saima malik*, Aditya G. Lavekar and Bimal Krishna Banik*
The radical was first come into existence in 1900 by Gomberg, where the triphenylmethane radical was explored. Thus, even to date, two centuries have seen radical chemistry as the methodology of preference in organic synthesis. Due to the fascinating nature of the radical-mediated cyclization reactions, it always caught the eye of organic chemists for the synthesis of novel organic compounds with diverse stereochemistry. Moreover, the development of radical methods further proves beneficial for the synthesis by providing atom- and step-economical methods to complex molecules. Among these, where radical chemistry has been employed, the use of tin-based radical annulation is the most common and widely used field for the synthesis of a wide range of organic reactions with medicinal importance. In this review, we compiled recent tin-mediated radical cyclization reactions toward the synthesis of molecules of biological significance.
tin metal, annulation, radical cyclization, radical cyclization, medicinal importance, synthesis
Department of Chemistry Panjab University, Sector-14, Chandigarh, Former Research Scholar at Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow-226031, College of Sciences and Human Studies; Deanship of Research Development; Prince Mohammad Bin Fahd University, P. O. Box 1664; Al Khobar 31952