Submit Manuscript  

Article Details

Michael Addition-initiated Sequential Reactions from 1,3-dicarbonyls for the Synthesis of Polycyclic Heterocycles

[ Vol. 17 , Issue. 18 ]


Xavier Bugaut, Damien Bonne, Yoann Coquerel, Jean Rodriguez and Thierry Constantieux   Pages 1920 - 1928 ( 9 )


This review aims to highlight the most significant recent developments on synthetic strategies involving consecutive, domino and multicomponent reactions featuring a Michael addition-initiating step for the synthesis of polycyclic heterocycles from 1,3- dicarbonyls. These original sequences constitute more efficient and eco-compatible alternatives to known synthetic approaches to heterocyclic compounds allowing for an even faster and highly desirable generation of molecular diversity and complexity.


Consecutive reactions, Domino reactions, Multicomponent reactions, Michael addition, Polycyclic heterocycles, 1, 3-Dicarbonyl compounds.


Aix Marseille Universite, CNRS, iSm2 UMR 7313, 13397, Marseille, France.

Read Full-Text article