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Synthesis of Aminophosphines and Their Applications in Catalysis

[ Vol. 16 , Issue. 24 ]


Valeria A. Stepanova and Irina P. Smoliakova   Pages 2893 - 2920 ( 28 )


The review describes preparation of P,N-bidentate ligands without a P–N bond and their use in asymmetric catalysis. Diverse types of aminophosphines are considered with emphasis on P,N-ferrocene ligands, phosphino-oxazolines and phosphinopyridines. The following major synthetic approaches to aminophosphines and related compounds are summarized: (i) via lithiation, (ii) the use of Grignard reagents, (iii) nucleophilic substitution using metal phosphides, (iv) Staudinger method, (v) hydrophosphination of α,β-unsaturated carbonyl compounds, (vi) Cu- and Pd-catalyzed C–P bond formation reactions, and (vii) reactions of cyclopalladated complexes with metal phosphides and HPPh2. Highlights of aminophosphine applications in asymmetric synthesis include their use in hydrogenation, hydrosilylation, and hydroboration reactions as well as in various transformations leading to a C–C bond formation such as Suzuki coupling, Meerwein-Eschenmoser-Claisen rearrangement, Mukaiyama aldol reaction, Tsuji allylation and ethylene oligomerization.


C–P bond formation reactions, P, N-bidentate ligands, Aminophosphines, Ferrocene-based aminophosphines, Phosphinooxazolines, phosphinopyridines


Department of Chemistry, University of North Dakota, 151 Cornell Street, Mail Stop 9024, Grand Forks, ND 58202-9024, USA.

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