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New Approaches to Nitrogen Containing Heterocycles: Enantioselective Organocatalyzed Synthesis of Dihydropyridines (DHP's), Quinolizidine Derivatives and Dihydropyrimidines (DHPM's)

[ Vol. 16 , Issue. 15 ]


Hoai T. Pham, Isabelle Chataigner and Jean-Luc Renaud   Pages 1754 - 1775 ( 22 )


Nitrogen-containing heterocycles, and more specifically the chiral ones, possess various biological and pharmaceutical properties. Among the approaches to these compounds, the organocatalyzed asymmetric multicomponent reaction has emerged as a powerful tool. This review will focus on the later development to chiral dihydropyridines, dihydropyrimidines and quinolizidines via asymmetric organocatalyzed synthesis....


Dihydropyridines, Dihydropyrimidines, Quinolizidines, Chiral Brønsted acids, Chiral thioureas, Proline type derivatives, multicomponent condensation, cyclization, chiral pocket, Bronsted acids


UMR CNRS 6507 LCMT, University of Caen – ENSICAEN, Avenue du Marechal Juin, 14050 Caen (France).

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