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Applications of the in situ Propargyl-Allenyl Isomerization in Organic Synthesis

[ Vol. 16 , Issue. 13 ]

Author(s):

Yanpeng Xing, Yuxiu Wei and Hongwei Zhou   Pages 1594 - 1608 ( 15 )

Abstract:


Allenes have been shown to be versatile building blocks in organic synthesis. However, the diversity of the allene chemistry offers a challenging and exquisite task for organic chemists bent on building the suitable allene substrates. A good solution might be propargyl-allenyl isomerization, which means to prepare readily available propargyl substrates. This review focuses on recent progress in the in situ propargyl-allenyl isomerization in organic synthesis, published in 1990 and later.

Keywords:

Propargyl-allenyl isomerization, Allene, Cyclization, Base-promotion, Propargyl Ether, coupling–isomerization–Claisen, sulfur (selenium), bis-propargylic sulfides, cycloaddition, nitrogen

Affiliation:

Department of Chemistry, Zhejiang University (Campus Xixi), Hangzhou, 310028, China.



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