Submit Manuscript  

Article Details


Iron Nanoparticles-Catalyzed Electrophilic Amination of Functionalized Organocopper and Organozinc Reagents

[ Vol. 16 , Issue. 11 ]

Author(s):

Sukalyan Bhadra, Sabir Ahammed and Brindaban C. Ranu   Pages 1453 - 1460 ( 8 )

Abstract:


The electrophilic amination of functionalized organocopper and organozinc reagents by N,N-dialkyl-O-benzoyl hydroxylamine derivatives to provide functionalized tertiary aryl amines has been accomplished efficiently at ambient temperature using in situ generated Fe(0) nanoparticles from Fe(acac)3. The formation and role of Fe(0)-nanoparticles were investigated. The mechanism involving Feassisted nucleophilic displacement at the nitrogen centre of the hydroxylamine derivative by the Cu/Zn-reagents is described. The organo- copper/zinc reagents are readily prepared by the treatment of the corresponding Grignard reagents with CuI and ZnCl2 respectively.

Keywords:

Electrophilic amination, Tertiary aryl amines, Organocopper reagent, Organozinc reagent, Iron(0) nanoparticles

Affiliation:

Department of Organic Chemistry, Indian Association for the cultivation of Science, Jadavpur, Kolkata - 700032, India.



Read Full-Text article