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Binaphthyl-Derived Mono-, Bi- and Multi-Functional Lewis and Brønsted Base Organocatalysts: A New Vista for Asymmetric Synthesis

[ Vol. 15 , Issue. 13 ]

Author(s):

Matthias Freund, Sebastian Schenker, Alexandru Zamfir and Svetlana B. Tsogoeva   Pages 2282 - 2310 ( 29 )

Abstract:


Lewis and Bronsted base catalysis are rapidly growing areas in organocatalysis. Numerous binaphthyl-derived chiral base catalysts has been developed over the last years. Recent progress in the chiral Lewis and Bronsted base catalysis has been reviewed with a focus being placed on mono-functional catalysts, including primary and secondary diamines, guanidines, phosphines and phosphineoxides; bi- and multifunctional catalysts, covering secondary and/or tertiary amine and phosphine derivatives assisted with urea/thiourea hydrogen bond donors or Lewis/ Bronsted acids.

Keywords:

Asymmetric organocatalysis, bi-/multi-functional catalysis, binaphthyl-derived organocatalysts, Bronsted bases, Lewis bases, urea/thioureas, Primary Diamines, Guanidine Derivatives, Secondary Diamines, Chiral Phosphineoxides, Alcohol-Assisted Tertiary Amines, B- OR LI-BINOL COMPLEXES, phase transfer catalysts (PTC), tetramethylguanidine (TMG), chemoselective

Affiliation:

Department of Chemistry and Pharmacy, Chair of Organic Chemistry I, University of Erlangen-Nuremberg, Henkestrasse 42, 91054 Erlangen, Germany.



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