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Cycloaddition of Alkynes: Atom-Economic Protocols for Constructing Six-Membered Cycles

[ Vol. 15 , Issue. 5 ]


Ruimao Hua, Maria Victoria A. Abrenica and Ping Wang   Pages 712 - 729 ( 18 )


Recent advances on the synthesis of six-membered carbo- and heterocyclic compounds including functionalized benzenes, 1,3- cyclohexadienes, pyridines, pyridones, pyranones, coumarins and isocoumarins via the cycloaddition reaction of alkynes are reviewed. Special attention is paid to atom-economic controllable chemo- and regioselective reactions, which are currently extremely attractive methodologies in organic synthesis.


Alkynes, cycloaddition, carbocycles, heterocycles


Department of Chemistry, Tsinghua University, Beijing 100084, China.

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