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Recent Advances in the Synthesis and Application of Bismuth-Containing Heterocyclic Compounds

[ Vol. 15 , Issue. 5 ]

Author(s):

Shigeru Shimada   Pages 601 - 620 ( 20 )

Abstract:


This review overviews the advances in the chemistry of bismuth-containing heterocyclic compounds during the last decade. Some new types of bismuth-containing heterocyclic systems containing nitrogen, oxygen, sulfur and/or phosphorus in addition to bismuth have been synthesized. 5,6,7,12-Tetrahydrodibenz[c,f][1,5]azabismocine derivatives were the most extensively studied bismuthcontaining heterocyclic compounds during the last decade, and a number of new compounds were synthesized. Their application to organic synthesis has shown that they are useful as reagents for the cross-coupling reaction with organic halides and as Lewis acid catalysts. Also they were used for the fixation of CO2. Some pentavalent bismuth-containing heterocyclic compounds were found to be useful in organic synthesis. Biological activity of some of bismuth-containing heterocyclic compounds was studied and found to show antimicrobial, antibacterial, antifungal, and anticancer activities.

Keywords:

Bismuth, Heterocyclic Compounds, Hypervalent Compounds, Organic Synthesis, Biological Activities

Affiliation:

National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5, 1–1–1 Higashi, Tsukuba, Ibaraki 305–8565, Japan.



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