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Recent Advances on Synthesis of 1,4-Benzoxazines and its Derivatives

[ Vol. 25 , Issue. 23 ]

Author(s):

Wei Liang, Li-Jing Min, Liang Han and Xing-Hai Liu*   Pages 2840 - 2855 ( 16 )

Abstract:


1,4-benzoxazine compounds are an important class of heterocyclic compounds. Ever since 1,4-benzoxazine was discovered in 1959, it has attracted chemists due to its unique physiological activities, and their synthesis and application have been studied. However, the traditional synthesis methods of 1,4-benzoxazines have some drawbacks, such as complicated steps, harsh reaction conditions and low yield. Therefore, it is still a significant direction to develop new and efficient synthesis methods. In this paper, the synthesis methods and reaction mechanisms of these compounds are reviewed, and the application prospect of 1,4- benzoxazine and its derivatives as a dominant active structure in the future is discussed.

Keywords:

1, 4-benzoxazines, derivatives, heterocyclic compounds, application, synthesis methods, reaction mechanisms.

Affiliation:

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, College of Life Science, Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, Huzhou University, Huzhou, 313000, Zhejiang, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang



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