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Multicomponent Approach for the Sustainable Syntheses of Pyrido[2,3-d]pyrimidine Scaffold

[ Vol. 25 , Issue. 23 ]


Ankita Chaudhary*   Pages 2856 - 2884 ( 29 )


Pyrido[2,3-d]pyrimidine is an N-fused heterocyclic compound formed by the ortho fusion of pyridine and pyrimidine ring. Pyrido[2,3-d]pyrimidines hold a prominent position in medicinal chemistry owing to their wide spectrum of biological activities like antiviral, antihistaminic, antibacterial, diuretic, anti-inflammatory, analgesic, anticonvulsive, antipyretic, etc. The extraordinary features of pyrido[2,3-d]pyrimidines make their synthesis a perpetual field of research. Moreover, the construction of elaborate biologically relevant moieties via a multicomponent approach has become a promising area of research, owing to the burgeoning ‘green chemistry drive’. Advances in the exploitation of proficient synthetic routes involving a multicomponent approach for the assembly of this scaffold are reported in this review.


Pyrido[2, 3-d]pyrimidine, multicomponent reactions, fused heterocycles, one-pot synthesis, sustainable chemistry, biological activities.


Department of Chemistry, Maitreyi College, University of Delhi, New Delhi

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