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Recent Advances in Microwave-Assisted Synthesis and Functionalization of 1,2,3- and 1,2,4-triazoles

[ Vol. 25 , Issue. 23 ]

Author(s):

Daiana Portella Franco, Lucas Caruso, Nathalia Fonseca Nadur, Thiago Moreira Pereira, Renata Barbosa Lacerda and Arthur Eugen Kümmerle*   Pages 2815 - 2839 ( 25 )

Abstract:


Triazoles are five-membered aromatic heterocyclics, which exhibit two isosteric forms (1,2,3-triazoles and 1,2,4-triazoles), as well as multiple applications in medicinal, agricultural, supramolecular, and materials sciences. Famous examples of triazoles include drugs, such as fluconazole, ribavirin, cefatrizine, and tazobactam, as well as herbicides, such as cafenstrole and metosulam. This review aims to present the recent major examples of the application of microwave-assisted organic synthesis (MAOS) to the syntheses and endfunctionalizations of 1,4- and 1,5-disubstituted 1,2,3-triazoles, 1,2,4-triazoles, 3-amino-1,2,4- triazoles, 1,2,4-triazol-3-one, and 1,2,4-triazol-3-thiol derivatives. Notably, the previous reviews on triazole syntheses have not exclusively elucidated the relevance of MAOS techniques in the obtention and derivatization of these compounds.

Keywords:

1, 2, 3-triazoles, 1, 2, 4-triazoles, microwave-assisted synthesis, heterocycles, classical heating methods, microwave irradiation.

Affiliation:

Laboratório de Diversidade Molecular e Química Medicinal (LaDMol-QM, Molecular Diversity and Medicinal Chemistry Laboratory), Chemistry Institute, Rural Federal University of Rio de Janeiro, Seropédica, 23897-000, Rio de Janeiro, Laboratório de Diversidade Molecular e Química Medicinal (LaDMol-QM, Molecular Diversity and Medicinal Chemistry Laboratory), Chemistry Institute, Rural Federal University of Rio de Janeiro, Seropédica, 23897-000, Rio de Janeiro, Laboratório de Diversidade Molecular e Química Medicinal (LaDMol-QM, Molecular Diversity and Medicinal Chemistry Laboratory), Chemistry Institute, Rural Federal University of Rio de Janeiro, Seropédica, 23897-000, Rio de Janeiro, Laboratório de Diversidade Molecular e Química Medicinal (LaDMol-QM, Molecular Diversity and Medicinal Chemistry Laboratory), Chemistry Institute, Rural Federal University of Rio de Janeiro, Seropédica, 23897-000, Rio de Janeiro, Programa de Pós-Gradução em Química (PPGQ), Universidade Federal Rural do Rio de Janeiro, Seropédica, 23897-000, Rio de Janeiro, Laboratório de Diversidade Molecular e Química Medicinal (LaDMol-QM, Molecular Diversity and Medicinal Chemistry Laboratory), Chemistry Institute, Rural Federal University of Rio de Janeiro, Seropédica, 23897-000, Rio de Janeiro



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