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Antifungal and Allelopathic Activities of Sesquiterpenes from Solidago canadensis

[ Vol. 25 , Issue. 21 ]

Author(s):

Na Liu*, Meina Song, Yulin Sun, Fengying Yang, Haina Yu, Cong Wu, Yilin Sun, Wenqiang Chang*, Di Ge* and Hua Zhang*   Pages 2676 - 2682 ( 7 )

Abstract:


One new eudesmane sesquiterpene 1 and one new chromolaevane sesquiterpene 2, along with 19 known compounds, have been isolated from the invasive plant Solidago canadensis. Their structures were established by spectroscopic means, including 1D/2D-NMR and HR-ESIMS analyses. Compounds 10 and 12, in combination with fluconazole, showed significant activity in an in vitro synergistic antifungal assay against Candida albicans, with FIC values of <0.15625 and <0.28125, respectively. Meanwhile, the allelopathic effects of these sesquiterpenes on Arabidopsis seed germination were also tested. Compounds 5, 7, 17 and 18 retarded the seed germination of Arabidopsis with IC50 values ranging from 9.1 to 41 μg/mL, while other compounds showed no obvious inhibitory effects.

Keywords:

Solidago canadensis, sesquiterpene, antifungal activity, allelopathic activity, NMR data, HMBC.

Affiliation:

School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, Key Lab of Chemical Biology of Ministry of Education, Shandong University, 44 West Wenhua Road, Jinan 250012, School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022

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