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Reduction of Oximes and Hydrazones: Asymmetric and Diastereoselective Approaches

[ Vol. 25 , Issue. 19 ]

Author(s):

João L.P. Ribeiro, Cláudia Alves, Ana L. Cardoso, Susana M.M. Lopes and Teresa M.V.D. Pinho e Melo*   Pages 2175 - 2198 ( 24 )

Abstract:


The asymmetric reduction of oximes and hydrazones is an attractive and versatile strategy for the synthesis of chiral amines, which are valuable building blocks in organic synthesis. This review summarizes the relevant developments made in the last decade on the enantioselective and diastereoselective reduction of oximes and hydrazones involving metalcatalyzed hydrogenation/hydrogenolysis reactions, hydride donor reactions, and electrochemical reactions.

Keywords:

Chiral amines, asymmetric reduction, enantioselective reduction, diastereoselective reduction, oximes, chiral hydroxylamines, hydrazones, chiral hydrazines.

Affiliation:

University of Coimbra, Coimbra Chemistry Centre and Department of Chemistry, 3004-535 Coimbra, University of Coimbra, Coimbra Chemistry Centre and Department of Chemistry, 3004-535 Coimbra, University of Coimbra, Coimbra Chemistry Centre and Department of Chemistry, 3004-535 Coimbra, University of Coimbra, Coimbra Chemistry Centre and Department of Chemistry, 3004-535 Coimbra, University of Coimbra, Coimbra Chemistry Centre and Department of Chemistry, 3004-535 Coimbra

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