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Amide-Directed Reactions of Small Carbocycles

[ Vol. 25 , Issue. 14 ]

Author(s):

Pavel M. Yamanushkin, Marina Rubina and Michael Rubin*   Pages 1686 - 1703 ( 18 )

Abstract:


The topic of this review is the amide-directed functionalization of strained carbocycles - specifically, unsaturated or saturated three- and four-membered rings. The following approaches are discussed: a) directed carbometallation and hydrometallation of cyclopropenes catalyzed by transition metals; b) directed metal-templated nucleophilic addition reactions; c) directed C-H functionalization, including transition metal-catalyzed C-H-activation reactions; and d) directed radical additions.

Keywords:

Small cycles, directing groups, nucleophilic addition, C-H activation, transition metal-catalysis, radical additions.

Affiliation:

Department of Chemistry, University of Kansas, 1567 Irving Hill Road – Lawrence, KS 66045, Department of Chemistry, University of Kansas, 1567 Irving Hill Road – Lawrence, KS 66045, Department of Chemistry, University of Kansas, 1567 Irving Hill Road – Lawrence, KS 66045

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