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Tin-Mediated Radical Cyclization Reactions

[ Vol. 25 , Issue. 22 ]

Author(s):

Saima malik*, Aditya G. Lavekar and Bimal Krishna Banik*   Pages 2708 - 2739 ( 32 )

Abstract:


Radical chemistry is known for two centuries. Due to the fascinating nature of the radical-mediated processes, these reactions have attracted the attention of organic chemists to prepare new compounds with diverse stereochemistry. Radical-induced methods mostly follow atom economical principles. Tin-based radical annulation method is the most common and widely used procedure for the synthesis of a wide range of organic compounds with medicinal significance. In this review, we report recent stereoselective tin-mediated radical cyclization reactions. The versatility of tinbased reagents in the cyclization process as reported herein will encourage chemists to construct many other molecules of interest following the principles involved in these reactions.

Keywords:

Carbon-carbon bond, tin, annulation, radical cyclization, stereochemistry, radical mediated.

Affiliation:

Department of Chemistry, Panjab University, Sector-14, Chandigarh, Medicinal and Process Chemistry Division, CSIRCentral Drug Research Institute, Lucknow-226031, College of Sciences and Human Studies; Prince Mohammad Bin Fahd University, P.O. Box 1664; Al Khobar 31952



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