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Peptidomimetics and Peptide-Based Blockbuster Drugs

[ Vol. 25 , Issue. 14 ]


Jianlin Han, Hiroyuki Konno, Tatsunori Sato, Kunisuke Izawa* and Vadim A. Soloshonok*   Pages 1627 - 1658 ( 32 )


Amino acids (AAs) play an important role in the modern health industry. The aim of this article was to assess that AAs’ residues are frequently found in the structures of smallmolecule modern pharmaceuticals, while peptidomimetics and peptide-based drugs are entirely derived from AAs. Currently, AAs serve as key structural features in numerous successful pharmaceuticals, so-called blockbuster drugs. In this work, we provide a detailed profile of 5 peptidomimetics and 4 peptide drugs. For each compound, we describe the spectrum of biological activity, medicinal chemistry discovery, and synthetic preparation.


Tailor-made amino acids, blockbuster drugs, peptidomimetic, peptides, modern pharmaceuticals, drug design and development, asymmetric synthesis.


Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037 Jiangsu, Department of Biological Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa, Yamagata 992-8510, Hamari Chemical Ltd., 1-19-40, Nankokita, Suminoe- ku, Osaka, 559-0034, Hamari Chemical Ltd., 1-19-40, Nankokita, Suminoe- ku, Osaka, 559-0034, Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, 20018 San Sebastian

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