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Recent achievements in the synthesis of oxazoles

Author(s):

Dau Xuan Duc* and Nguyen Thi Chung  

Abstract:


Oxazole-containing compounds have diverse biological activities, such as antimicrobial, anticancer, antitubercular, anti-inflammatory, antidiabetic, antiobesity, antimalarial, and antiviral activities, and some of them have been used as drugs for disease treatment. They also play important roles in the synthesis of bioactive natural products, pharmaceuticals, and synthetic transformations, as well as in materials, catalysts, and agricultural fields. Thus, the development of more efficient and facile synthetic approaches to access oxazole compounds has attracted the intensive interest of chemists, and diverse methods for their synthesis have been investigated. Various established methods have been improved and modified, while numerous novel methods have been discovered. This article summarizes considerable studies on the construction of the oxazole skeleton, which date back to 2014.

Keywords:

Toluenesulfonylmethyl isocyanide, 2-acylamino-ketones, propargylamides, 5-exo-dig cyclization, multisubstituted oxazoles, anti-inflammatory

Affiliation:

Department of Chemistry, Vinh University, Vinh City, Department of Chemistry, Vinh University, Vinh City



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