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Advancements in the Functionalization of Aryl C-sp2 and Alkyl C-sp3 of Toluene Derivatives via C-H Activation

Author(s):

Kevin George and Sathananthan Kannadasan *  

Abstract:


Toluene and its derivatives became well established as versatile scaffolds in organic synthesis over the last few decades. This review provides a brief and concise overview of the current status and latest methodologies in the synthetic utility of toluene and its derivatives by exploiting both the alkyl-sp3 and aryl-sp2 carbons via C-H activation. The review also explores the effect of various substituents on the toluene derivatives in facilitating different reactions.

Keywords:

toluene, C-H activation, C-C Coupling, C-Heteroatom bond formation, cross dehydrogenative coupling, Directing groups

Affiliation:

Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamil Nadu, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamil Nadu



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