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Mutasynthesis of Medicinally Significant Natural Products through the Manipulation of Gene Governing Starter Unit


Parul Grover, Deepak K Sharma, Anuj K. Chhalodia and Debaraj Mukherjee*  


Most of the biologically active microbial natural products and their analogs bear a complex molecular architecture. The semisynthetic modifications and stereospecific diversity-oriented synthesis of these native natural products to generate analogs are difficult and time-consuming. Mutasynthesis is a powerful tool that utilizes the microorganism's genetic and metabolic engineering skills to produce derivatives of complex natural products of microbial origin. Mutasynthesis is based on the cellular uptake of chemically modified intermediates from the culture media and their addition to the secondary metabolism by mutant microorganisms. This review wouldf describe the importance of mutasynthesis in the generation of complex microbial secondary metabolites. We have covered a literature search on mutasynthesis over the last ten years (2011 - 2020) in this review.


Mutasynthesis, Precursor-directed biosynthesis, Gene, Biosynthesis, Combinatorial, Secondary metabolite


KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad, 201206, Department of Pharmaceutical Engg. and Tech., Indian Institute of Technology-Banaras Hindu University, Varanasi, Uttar Pradesh, Kekule-Institute of Organic and Biochemistry, Rheinische Friedrich-Wilhelms-Universitat Bonn, Natural Product Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001

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