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Exploiting Microwave-Assisted Organic Synthesis (MAOS) for Accessing Bioactive Scaffolds

Author(s):

Ashish Khanna, Prashant Dubey and Ram Sagar*  

Abstract:


Microwave-assisted organic synthesis is an alternative approach towards the traditional way of heating to obtain desired bioactive scaffolds as a product. This method transformed the approaches of organic synthesis due to shorter reaction time with high product yields, modifications of selectivity, increased product purities and simplification of work-up procedures. The microwave-assisted reactions can be performed under solvent-free conditions. Thus, microwave-assisted organic synthesis (MAOS) became the first choice for the medicinal chemist and chemical biologist to use this as a tool to perform organic reactions in the area of drug discovery and medicinal chemistry. Microwave-assisted organic synthesis specifically results in the desired products with higher selectivity and purity which may have better pharmacological properties. In this review article, we covered the literature starting from 2010- to date focussing on the use of microwave irradiation in performing organic reactions in order to deliver various bioactive scaffolds.

Keywords:

Microwave-assisted organic synthesis, bioactivity, anti-bacterial, anti-tubercular, anti-fungal, anti-viral, anti-cancer, anti-malarial, anti-leishmania, anti-inflammatory, anti-oxidant, anti-coagulant, anti-diabetic.

Affiliation:

Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi- 221005, Centre of Material Sciences, Institute of Interdisciplinary Studies (IIDS), University of Allahabad, Prayagraj-211002, Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi- 221005



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