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Condensed Pyridopyrimidines and Pyridopyrazines Containing a Bridgehead Nitrogen Atom: Synthesis, Chemical Properties and Biological Activity

Author(s):

Mikhail V. Slivka and Natali I. Korol*   Pages 1 - 12 ( 12 )

Abstract:


The investigation of effective and green synthetic routes to approach to novel fused heterocycles with pyridopyrimidine and pyridopyrazine scaffolds stirs up broad interest from scientists as they are capable of providing valuable properties such as anticancer and antimicrobial activities and they are proved γ-secretase modulators, polymers, and corrosion inhibitors. This causes a steady increase in the number of publications on titled condensed systems. The present review article summarizes recent literature data from 2010 to 2020 on the methods of synthesis, chemical transformations and biological properties of condensed bicyclic systems of pyridopyrimidine and pyridopyrazine with a bridgehead nitrogen atom to establish the current state of the art in this area.

Keywords:

Pyrido[1, 2-a]pyrimidines, pyrido[1, 2-a]pyrazines, pyrido[1, 2-c]pyrimidines, bridgehead nitrogen atom, reactivity, biological activity.

Affiliation:

Organic chemistry department, Faculty of Chemistry, Uzhhorod National University, Uzhhorod, Organic chemistry department, Faculty of Chemistry, Uzhhorod National University, Uzhhorod



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