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Formation of Carbon-Nitrogen Bond Mediated by Hypervalent Iodine Reagents Under Metal-free Conditions

[ Vol. 25 , Issue. 1 ]

Author(s):

Yaxin O. Yang, Xi Wang, Jiaxi Xiao, Yadong Li, Fengxia Sun* and Yunfei Du*   Pages 68 - 132 ( 65 )

Abstract:


In the past several decades, hypervalent iodine chemistry has witnessed prosperous development as hypervalent iodine reagents have been widely used in various organic transformations. Specifically, hypervalent iodine reagents have been vastly used in various bondforming reactions. Among these oxidative coupling reactions, the reactions involving the formation of C-N bond have been extensively explored to construct various heterocyclic skeletons and synthesize various useful building blocks. This review article is to summarize all the transformations in which carbon-nitrogen bond formation occurred by using hypervalent iodine reagents under metal-free conditions.

Keywords:

Hypervalent iodine reagent, oxidative coupling, C-N bond formation, oxidation, metal-free conditions, rearrangement.

Affiliation:

Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology; Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072



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