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Cyclotriphosphazene-based Derivatives for Antibacterial Applications: An Update on Recent Advances

[ Vol. 25 , Issue. 2 ]

Author(s):

Xiqi Su, Le Wang*, JingHua Xie, XiaoHui Liu and Helena Tomás   Pages 301 - 314 ( 14 )

Abstract:


As a phosphorus scaffold, hexachlorocyclotriphosphazene (HCCP) is widely used for the synthesis of varieties of derivatives, including metal-binding complexes and several unique organometallic compounds, which exhibit potential catalytic, flame retardant and biological activities. Some metal-binding HCCP derivatives have shown antibacterial activities as free ligands and metal complexes. These derivatives can also serve as building blocks for the formation of antibacterial metal-containing polymers. This mini-review is focused on the design and development of HCCP derivatives as potential antibacterial agents with representative examples as well as antibacterial mechanisms from recent years.

Keywords:

Hexachlorocyclotriphosphazene(HCCP), antibacterial, antibacterial mechanism, metal, ligand, polymer.

Affiliation:

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, CQM-Centro de Quimica da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal

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