Andrea Verónica Rodríguez-Mayor, German Jesid Peralta-Camacho, Karen Johanna Cárdenas-Martínez and Javier Eduardo García-Castañeda* Pages 1 - 23 ( 23 )
Glycoproteins and glycopeptides are an interesting focus of research, because of their potential use as therapeutic agents, since they are related to carbohydrate-carbohydrate, carbohydrate-protein, and carbohydrate-lipid interactions, which are commonly involved in biological processes. It has been established that natural glycoconjugates could be an important source of templates for the design and development of molecules with therapeutic applications. However, isolating large quantities of glycoconjugates from biological sources with the required purity is extremely complex, because these molecules are found in heterogeneous environments and in very low concentrations. As an alternative for solving this problem, the chemical synthesis of glycoconjugates has been developed. In this context, several methods for the synthesis of glycopeptides in solution and/or solid phase have been reported. In most of these methods, glycosylated amino acid derivatives are used as building blocks for both solution and solid-phase synthesis. The synthetic viability of the glycoconjugates is a critical parameter for allowing their use as drugs to mitigate the impact of microbial resistance and/or cancer. However, the chemical synthesis of glycoconjugates is a challenge, because these molecules possess multiple reaction sites and have a very specific stereochemistry. Therefore, it is necessary to design and implement synthetic routes, which may involve various protection schemes but can be stereoselective, environmentally friendly, and high-yielding. This review focuses on glycopeptide synthesis by recapitulating the progress made over the last 15 years.
Glycopeptides, glycosidic linkage, building blocks, glycosylated amino acid, solid phase peptide synthesis, click chemistry.
Chemistry Department, Universidad Nacional de Colombia, Bogotá, Chemistry Department, Universidad Nacional de Colombia, Bogotá, Pharmacy Department Sciences Faculty, Universidad Nacional de Colombia, Bogotá, Pharmacy Department Sciences Faculty, Universidad Nacional de Colombia, Bogotá