Jiale Xiong, Xiaoyun Zhao, Xing Feng and Jiang Xianxing* Pages 1 - 12 ( 12 )
An efficient decarboxylative cycloaddition of 2,3-dioxopyrrolidines and ethynyl benzoxazinanones has been established by cooperative copper/amine catalysis. A copper–allenylidene complex and enolate intermediate, each catalytically generated from distinct substrates, underwent a cascade propargylation/hydroamination/aromatization process to construct a big library of cyclopenta[b]indole derivatives with good to excellent yields and excellent diastereoselectivity.
Cooperative catalysis, cascade reaction, cyclopenta[b]indole, ethynyl benzoxazinanone, 2, 3-dioxopyrrolidine, copper–allenylidene.
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006