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Arylpyrazoles: Heterocyclic Scaffold of Immense Therapeutic Application

[ Vol. 24 , Issue. 14 ]

Author(s):

Garima Tripathi, Anil Kumar Singh* and Abhijeet Kumar*   Pages 1555 - 1581 ( 27 )

Abstract:


Among the major class of heterocycles, the N-heterocycles, such as pyrazoles, are scaffolds of vast medicinal values. Various drugs and other biologically active molecules are known to contain these N-heterocycles as core motifs. Specifically, arylpyrazoles have exhibited a diverse range of biological activities, including anti-inflammatory, anticancerous, antimicrobial and various others. For instance, arylpyrazoles are present as core moieties in various insecticides, fungicides and drugs such as Celebrex and Trocoxil. The present review will be highlighting the significant therapeutic importance of pyrazole derivatives developed in the last few years.

Keywords:

Pyrazole, anti-inflammatory, anti-malarial, anti-cancerous, anti-viral, antifungal.

Affiliation:

Department of Chemistry, T. N. B. College, Tilka Manjhi Bhagalpur University, Bhagalpur, Bihar, Department of Chemistry, School of Physical Sciences, Mahatma Gandhi Central University, Bihar, Department of Chemistry, School of Physical Sciences, Mahatma Gandhi Central University, Bihar

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