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Recent Advances in the Exploitation of Kojic Acid in Multicomponent Reactions


Ankita Chaudhary*   Pages 1 - 20 ( 20 )


Kojic acid, one of the most widespread 3-hydroxypyran-4-one derivatives, display wide range of biological activities and found application in food as well as cosmetics industry. The synthesis of kojic acid derivatives has provoked great interest as easily available and biologically active precursor among the organic and medicinal researchers. Multi-component reactions, involving three or more reactants in one-pot thereby resulting into a structure with functional diversity are efficient method for the promotion of green chemistry in the context of modern drug discovery. They offer several advantages over conventional stepwise protocols like simplicity, efficiency, selectivity, convergence and atom economy. This review aims to highlight the versatility of kojic acid as an important synthon in multicomponent reactions for the construction of various biologically relevant compounds such as pyrano[3,2‐b]chromenediones, pyrano[3,2-b]pyrans, pyrano[2′,3′:5,6]pyrano[2,3‑b]pyridines, spiro[indoline-3,4’-pyrano[3,2-b]pyrans, 2-substitued kojic acid conjugates etc.


Kojic aid, multicomponent reactions, green chemistry, one pot synthesis, organic synthesis, heterocycles.


Department of Chemistry, Maitreyi College, University of Delhi, New Delhi

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