Submit Manuscript  

Article Details


Recent Trends in the Development of Novel Catalysts for Asymmetric Michael Reaction

Author(s):

Shagufta Kamal, Ameer Fawad Zahoor*, Sajjad Ahmad, Rabia Akhtar, Iqra Khaliq, Wajiha Qurban and Attia Mehreen   Pages 1 - 63 ( 63 )

Abstract:


Background: Michael reaction is the nucleophilic addition of active methylene compounds to conjugated olefins, resultantly affording a variety of biologically active scaffolds with high enantiopurity. To improve reaction yield as well as enantioselectivity of the product, a variety of catalysts (amine based catalysts, bifunctional L-proline amides, bifunctional squaramides, chiral ionic liquids, cinchona alkaloids, enzymes, indolinols, metal catalysts, peptide derived catalytic system, phase transfer catalysts, pyrrolidine based organocatalysts) have been investigated by different era of chemists. Besides this, different methodologies have been developed to improve reaction yield and enantioselectivity of the targeted products with low catalyst loading.

Conclusion: This review article provides a concise overview about the catalysts applied recently by different scientists in the Michael addition reaction. Moreover, current strategies and potential applications of this reaction have also been illustrated in this review.

Keywords:

Michael addition, michael acceptor, conjugate addition, N-heterocyclic carbene, asymmetric catalysis, oxa-michael reaction

Affiliation:

Department of Biochemistry, Government College University Faisalabad, Faisalabad-38000, Department of Chemistry, Government College University Faisalabad, Faisalabad-38000, Department of Chemistry, University of Engineering and Technology Lahore, Faisalabad Campus, Faisalabad-38000, Department of Chemistry, Government College University Faisalabad, Faisalabad-38000, Department of Chemistry, Government College University Faisalabad, Faisalabad-38000, Department of Chemistry, Government College University Faisalabad, Faisalabad-38000, Department of Chemistry, Government College University Faisalabad, Faisalabad-38000



Read Full-Text article