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Recent Advances in Biginelli-type Reactions

Author(s):

Majid M. Heravi* and Vahideh Zadsirjan   Pages 1 - 36 ( 36 )

Abstract:


The effective and high yielding synthesis of poly-functionalized pyrimidines, using multicomponent reactions (MCRs) is imperative in organic and medicinal chemistry. The classic Biginelli reaction is a typically one-pot threecomponent cyclocondensation reaction involving an aldehyde, a β-ketoester and urea resulting in the construction of multifunctionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs). In recent years, other active methylene compounds, various derivatives of urea and diversely substituted aldehydes have also been used, resulting in the preparation of a new series of various novel dihydropyrimidinones via the Biginelli-Type Reactions (BTRs) or modified Biginelli reactions (MBRs). In this review, we try to underscore the recent advances in BTRs or MBRs.

Keywords:

Biginelli reactions, multicomponent reactions, one-pot reaction, biginelli-type reactions, modified biginelli reactions, β-ketoester, urea, dihydropyrimidinones.

Affiliation:

Department of Chemistry, School of Science, Alzahra University, POBox 1993891176, Vanak, Tehran, Department of Chemistry, School of Science, Alzahra University, POBox 1993891176, Vanak, Tehran



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