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Recent Advances in Biginelli-type Reactions

[ Vol. 24 , Issue. 12 ]

Author(s):

Majid M. Heravi* and Vahideh Zadsirjan*   Pages 1331 - 1366 ( 36 )

Abstract:


The effective and high yielding synthesis of poly-functionalized pyrimidines, using multicomponent reactions (MCRs), is imperative in organic and medicinal chemistry. The classic Biginelli reaction is a typically one-pot three-component cyclocondensation reaction involving an aldehyde, a β-ketoester and urea, resulting in the construction of multi-functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs). In recent years, other active methylene compounds, various derivatives of urea and diversely substituted aldehydes have also been used, resulting in the preparation of a new series of various novel dihydropyrimidinones via the Biginelli-Type Reactions (BTRs) or modified Biginelli reactions (MBRs). In this review, we try to underscore the recent advances in BTRs or MBRs.

Keywords:

Biginelli reactions, multicomponent reactions, one-pot reaction, Biginelli-type reactions, modified Biginelli reactions, β- ketoester, urea, dihydropyrimidinones.

Affiliation:

Department of Chemistry, School of Science, Alzahra University, P.O. Box 1993891176, Vanak, Tehran, Department of Chemistry, School of Science, Alzahra University, P.O. Box 1993891176, Vanak, Tehran

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