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Bio-organometallic Peptide Conjugates: Recent Advances in their Synthesis and Prospects for Biomedical Application

Author(s):

Fanny Guzman*, Johana Gomez , Constanza Cárdenas and Diego Sierra   Pages 1 - 16 ( 16 )

Abstract:


One area of organometallic chemistry that has attracted great interest in recent years is the syntheses, characterization and study of organometallic complexes conjugated to biomolecules with different steric and electronic properties as potential therapeutic agents against cancer and malaria, as antibiotics and as radiopharmaceuticals. This mini-review focuses on the unique structural diversity that has recently been discovered in alpha-amino acids and the reactions of metallocene complexes with peptides having different chemical behavior and potential medical applications. Replacing alpha-amino acids with metallocene fragments is an effective way of selectively influencing the physicochemical, structural, electrochemical and biological properties of the peptides. Consequently, research in the field of bioorganometallic chemistry offers the opportunity to develop bioactive metal compounds as an innovative and promising approach in the search for pharmacological control of different diseases.

Keywords:

organometallic-peptide, metallocenes, sandwich structures, solid-phase peptide synthesis, biorganometallic chemistry, biological activity

Affiliation:

Pontifical Catholic University of Valparais, Curauma Biotechnology Nucleus, Av Universidad 330, Curauma Valparaiso Chile, Pontifical Catholic University of Valparais, Curauma Biotechnology Nucleus, Av Universidad 330, Curauma Valparaiso Chile , Pontifical Catholic University of Valparais, Curauma Biotechnology Nucleus, Av Universidad 330, Curauma Valparaiso Chile, University of Valparaíso, Institute of Chemistry and Biochemistry, Great Britain Avenue 1111, Valparaíso



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