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Recent Developments on the Synthesis of Biologically Significant bis/tris(indolyl)methanes under Various Reaction Conditions: A Review

[ Vol. 24 , Issue. 6 ]

Author(s):

Arvind Singh, Gurpreet Kaur and Bubun Banerjee*   Pages 583 - 621 ( 39 )

Abstract:


Bis(indolyl)methane skeleton is the main building block of many naturally occurring bioactive compounds. Bis(indolyl)methanes are found to possess a wide range of pharmaceuitical efficacies. These important scaffolds are being used as anti-cancer, antioxidant, anti-bacterial, anti-inflammatory, and anti-proliferative agents. In this review, we summarized the latest developments on the synthesis of various bis/tris(indolyl)methane derivatives from the reactions of two equivalents of indoles and one equivalent of aldehydes or indole-3-carbaldehydes under various reaction conditions. More than hundred different catalysts were employed for these transformations which include various metal catalysts, ionic liquids, organocatalysts, surfactants, homogeneous, heterogeneous catalysts etc.

Keywords:

Bis(indolyl)methanes, tris(indolyl)methanes, homogeneous catalysts, heterogeneous catalysts, biological activities, indole-3- carbaldehydes.

Affiliation:

Department of Chemistry, Indus International University, Village and Post Office Bathu, District Una, Himachal Pradesh, 174301, Department of Chemistry, Indus International University, Village and Post Office Bathu, District Una, Himachal Pradesh, 174301, Department of Chemistry, Indus International University, Village and Post Office Bathu, District Una, Himachal Pradesh, 174301

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