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Tetrazoloquinolines: Synthesis, Reactions, and Applications

[ Vol. 24 , Issue. 4 ]


Rizk E. Khidre*, Tahah A. Ameen and Mounir A. I. Salem   Pages 439 - 464 ( 26 )


This review summarizes the synthesis, reactions, and biological activities of tetrazolo[1,5-a]quinoline derivatives. These derivatives were synthesized by several methods such as i) from the reaction of 2-chloroquinoline with sodium azide ii) from diazotization 2-hydrazinylquinoline derivatives, and iii) from intramolecular cyclocondensation of 2-azidoarylidenes. Also, the chemical reactions and pharmacological activities of some tetrazoloquinolines such as tetrazolo[1,5-a]quinoline-4-carbaldehyde, 5-chlorotetrazolo[ 1,5-a]quinoline, 4-(chloromethyl)tetrazolo[1,5-a]quinoline, tetrazolo[1,5- a]quinoline-4-carboxylic acid, and 5-azidotetrazolo[1,5-a]quinoline were discussed.


Quinoline, tetrazoloquinoline, pyrimidine, pyrazole, heterocycles, pharmacological activities.


Chemistry Department, Faculty of Science, Jazan University, Jazan, Chemistry Department, Faculty of Science, Jazan University, Jazan, Department of Chemistry, Faculty of Science, Ain Shams University, Abbasia, Cairo

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