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Tetrazoloquinolines: Synthesis, Reactions, and Applications

[ Vol. 24 , Issue. 4 ]

Author(s):

Rizk E. Khidre*, Tahah A. Ameen and Mounir A. I. Salem   Pages 439 - 464 ( 26 )

Abstract:


This review summarizes the synthesis, reactions, and biological activities of tetrazolo[1,5-a]quinoline derivatives. These derivatives were synthesized by several methods such as i) from the reaction of 2-chloroquinoline with sodium azide ii) from diazotization 2-hydrazinylquinoline derivatives, and iii) from intramolecular cyclocondensation of 2-azidoarylidenes. Also, the chemical reactions and pharmacological activities of some tetrazoloquinolines such as tetrazolo[1,5-a]quinoline-4-carbaldehyde, 5-chlorotetrazolo[ 1,5-a]quinoline, 4-(chloromethyl)tetrazolo[1,5-a]quinoline, tetrazolo[1,5- a]quinoline-4-carboxylic acid, and 5-azidotetrazolo[1,5-a]quinoline were discussed.

Keywords:

Quinoline, tetrazoloquinoline, pyrimidine, pyrazole, heterocycles, pharmacological activities.

Affiliation:

Chemistry Department, Faculty of Science, Jazan University, Jazan, Chemistry Department, Faculty of Science, Jazan University, Jazan, Department of Chemistry, Faculty of Science, Ain Shams University, Abbasia, Cairo

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