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Electrochemical Detection of Neurotransmitters in the Brain and Other Molecules with Biological Activity on the Nervous System: Dopamine Analysis

Author(s):

Erika Bustos*, Juan Manríquez, Ana Laura Colín-González, Edgar Rangel-López and Abel Santamaría   Pages 1 - 10 ( 10 )

Abstract:


Monitoring the appropriate functions of the brain is prioritary when diagnosis of neurological diseases is carried out. In this sense, there are different analytical techniques to detect neurotransmitters and other molecules with biological activity on the nervous system. Among other analytical procedures, electrochemical techniques are very important since they can be applied in situ, without loss of sensibility and/or minimal handling of samples. In addition, it is also possible to combine them with specific detectors designed on the basis of chemically-modified electrodes in order to improve detection limits by promoting molecular recognition capabilities at their surfaces, thus favoring the development of electrochemical detection in vivo by microelectrodes. In this minireview, we will describe the major characteristics of this analytical method and its advantages for the detection of neurotransmitters (mostly dopamine) in vivo.

Keywords:

Electroanalysis, Neurotransmitters, Biological activity, Central Nervous System, Chromatography, Modified electrode

Affiliation:

Centro de Investigación y Desarrollo Tecnológico en Electroquímica, S.C., CIDETEQ, Parque Tecnológico Querétaro, Sanfandila, Pedro Escobedo, 76703, Querétaro, Centro de Investigación y Desarrollo Tecnológico en Electroquímica, S.C., CIDETEQ, Parque Tecnológico Querétaro, Sanfandila, Pedro Escobedo, 76703, Querétaro, Insttuto Nacional de Neurologia y Neurocirugia. Insurgentes Sur No. 3877, Mexico, D.F., C.P. 14269, Insttuto Nacional de Neurologia y Neurocirugia. Insurgentes Sur No. 3877, Mexico, D.F., C.P. 14269, Insttuto Nacional de Neurologia y Neurocirugia. Insurgentes Sur No. 3877, Mexico, D.F., C.P. 14269



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