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Review of Progress in Predicting Protein Methylation Sites

[ Vol. 23 , Issue. 15 ]

Author(s):

Chunyan Ao, Shunshan Jin, Yuan Lin * and Quan Zou*   Pages 1663 - 1670 ( 8 )

Abstract:


Protein methylation is an important and reversible post-translational modification that regulates many biological processes in cells. It occurs mainly on lysine and arginine residues and involves many important biological processes, including transcriptional activity, signal transduction, and the regulation of gene expression. Protein methylation and its regulatory enzymes are related to a variety of human diseases, so improved identification of methylation sites is useful for designing drugs for a variety of related diseases. In this review, we systematically summarize and analyze the tools used for the prediction of protein methylation sites on arginine and lysine residues over the last decade.

Keywords:

Protein methylation, Support Vector Machine (SVM), methyllysine, methylarginine, arginine residue, lysine residue, cysteine residues.

Affiliation:

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, Department of Neurology, Heilongjiang Province Land Reclamation Headquarters General Hospital, Harbin, Department of System Integration, Sparebanken Vest, Bergen, Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu



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