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Cyclodextrins and their Derivatives as Carrier Molecules in Drug and Gene Delivery Systems

[ Vol. 23 , Issue. 11 ]

Author(s):

Ramin Karimian and Milad Aghajani*   Pages 1266 - 1279 ( 14 )

Abstract:


Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides containing six (α-CD), seven (β-CD), eight (γ-CD) and more glucopyranose units linked with α-(1,4) bonds, having a terminal hydrophilic part and central lipophilic cavity. α-, β- and γ-CDs are widely used in many industrial products, technologies and analytical methods owing to their unique, versatile and tunable characteristics. In the pharmaceutical industry, CDs are used as complexing agents to enhance aqueous solubility, physico-chemical stability and bio-availability of administered drugs. Herein, special attention is given to use of α-, β- and γ-CDs and their derivatives in different areas of drug and gene delivery systems in the past few decades through various routes of administration with a major emphasis on the more recent developments.

Keywords:

Cyclodextrins, host-guest complexation, drug carriers, drug release, drug delivery systems, gene delivery systems.

Affiliation:

Chemical Injuries Research Center, Systems biology and poisonings institute, Baqiyatallah University of Medical Sciences, Tehran, Chemical Injuries Research Center, Systems biology and poisonings institute, Baqiyatallah University of Medical Sciences, Tehran



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