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Novel Chiral Ligands for Palladium-catalyzed Asymmetric Allylic Alkylation/ Asymmetric Tsuji-Trost Reaction: A Review

[ Vol. 23 , Issue. 11 ]

Author(s):

Samar Noreen, Ameer Fawad Zahoor*, Sajjad Ahmad, Irum Shahzadi, Ali Irfan and Sadia Faiz   Pages 1168 - 1213 ( 46 )

Abstract:


Background: Asymmetric catalysis holds a prestigious role in organic syntheses since a long time and chiral inductors such as ligands have been used to achieve the utmost desired results at this pitch. The asymmetric version of Tsuji-Trost allylation has played a crucial role in enantioselective synthesis. Various chiral ligands have been known for Pd-catalyzed Asymmetric Allylic Alkylation (AAA) reactions and exhibited excellent catalytic potential. The use of chiral ligands as asymmetric inductors has widened the scope of Tsuji-Trost allylic alkylation reactions.

Conclusion: Therefore, in this review article, a variety of chiral inductors or ligands have been focused for palladium catalyzed asymmetric allylic alkylation (Tsuji-Trost allylation) and in this regard, recently reported literature (2013-2017) has been described. The use of ligands causes the induction of enantiodiscrimination to the allylated products, therefore, the syntheses of various kinds of ligands have been targeted by many research groups to employ in Pd-catalyzed AAA reactions.

Keywords:

Asymmetric allylic alkylation, chiral ligands, diamidophosphite ligands, oxazolineligands, palladium catalysis, phosphine ligands.

Affiliation:

Department of Chemistry, Government College University Faisalabad, Faisalabad-38000, Department of Chemistry, Government College University Faisalabad, Faisalabad-38000, Department of Chemistry, University of Engineering and Technology Lahore, Faisalabad Campus, Faisalabad-38000, Department of Chemistry, Government College University Faisalabad, Faisalabad-38000, Department of Chemistry, Government College University Faisalabad, Faisalabad-38000, Department of Chemistry, Government College University Faisalabad, Faisalabad-38000



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