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Synthesis and In Vitro Antitumor Effect of New Vindoline-steroid Hybrids

[ Vol. 23 , Issue. 8 ]

Author(s):

András Keglevich, Vivian Zsiros, Péter Keglevich*, Áron Szigetvári, Miklós Dékány, Csaba Szántay, Erzsébet Mernyák, János Wölfling and László Hazai*   Pages 959 - 967 ( 9 )

Abstract:


10-Aminovindoline and 17-desacetylvindoline were coupled with 5α- dihydrotestosterone hemisuccinate and 19-nortestosterone hemisuccinate. As a result, four vindoline-steroid hybrids were synthesized via a succinate linker. One of the new hybrid compounds showed significant anticancer effect in vitro in the case of colon cancer and melanoma cell lines.

Keywords:

Vinca alkaloids, vindoline, steroid, succinate linker, hybrid molecules, antitumor activity.

Affiliation:

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellert ter 4, Quality Process Development Department, Egis Pharmaceuticals Plc., H-1106 Budapest, Kereszturi ut 30-38, Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellert ter 4, Spectroscopic Research Department, Gedeon Richter Plc., H-1475 Budapest, 10, P. O. Box 27, Spectroscopic Research Department, Gedeon Richter Plc., H-1475 Budapest, 10, P. O. Box 27, Spectroscopic Research Department, Gedeon Richter Plc., H-1475 Budapest, 10, P. O. Box 27, Department of Organic Chemistry, University of Szeged, H-6720 Szeged, Dom ter 8, Department of Organic Chemistry, University of Szeged, H-6720 Szeged, Dom ter 8, Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellert ter 4

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