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Synthesis and in vitro Antitumor Effect of New Vindoline Derivatives Coupled with Triphenylphosphine

[ Vol. 23 , Issue. 7 ]

Author(s):

András Keglevich*, Áron Szigetvári, Miklós Dékány, Csaba Szántay, Péter Keglevich and László Hazai*   Pages 852 - 858 ( 7 )

Abstract:


An important approach to the development of new antitumor agents is the synthesis of conjugates containing two or more structural units. Taking this into consideration, vindoline derivatives were coupled with triphenylphosphine, to afford the expected phosphonium salts. The new hybrid entities were characterized by NMR spectroscopy, and their anticancer activity was also evaluated.

Keywords:

Anticancer drugs, dimer Vinca alkaloids, vindoline, triphenylphosphine, phosphonium salts, antiproliferative activity.

Affiliation:

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellert ter 4, Spectroscopic Research Department, Gedeon Richter Plc., H-1475 Budapest, 10, P. O. Box 27, Spectroscopic Research Department, Gedeon Richter Plc., H-1475 Budapest, 10, P. O. Box 27, Spectroscopic Research Department, Gedeon Richter Plc., H-1475 Budapest, 10, P. O. Box 27, Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellert ter 4, Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellert ter 4

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