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Aminocoumarins: A Privileged Precursor for the Synthesis of Fused Heterocycles

[ Vol. 23 , Issue. 9 ]

Author(s):

Saigal, Sumbulunnisan Shareef, Habibur Rahman and Md. Musawwer Khan*   Pages 1045 - 1075 ( 31 )

Abstract:


Aminocoumarins are one of the important core structural systems, present in several biologically and medicinally active compounds. Owing to its natural occurrence, potential pharmacological applications and remarkable versatility as a privileged precursor, several proficient synthetic protocols have been reported in the literature over the past years. The presence of an amino group and enamine carbon enhances its chemical reactivity and thus such functionality is repeatedly used for the construction of various fused and simple heterocycles. This review highlights the preparation of different aminocoumarins and their applications for the construction of a variety of five, six and eight membered fused heterocycles.

Keywords:

Heterocycles, aminocoumarins, povarov reaction, multicomponent reactions, fused heterocycles, pharmacological activities.

Affiliation:

Department of Chemistry, Aligarh Muslim University, Aligarh, UP, 202002, Department of Chemistry, Aligarh Muslim University, Aligarh, UP, 202002, Department of General Studies, Jubail Industrial College, P.O. Box 10099, Zip Code-31961, Jubail, Department of Chemistry, Aligarh Muslim University, Aligarh, UP, 202002



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