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Recent Advances in Palladium-Catalyzed Oxidative Cyclizations

[ Vol. 23 , Issue. 9 ]

Author(s):

John C. Hershberger*   Pages 1019 - 1044 ( 26 )

Abstract:


Heterocycles are very common substructures in a number of pharmaceuticals. Over the past several years, the use of palladium-catalyzed oxidative cyclization for heterocyclic synthesis has become much more prevalent. This review collects recent reports using palladium catalysis to synthesize a wide variety of heterocyclic scaffolds. Many of these reactions use oxygen as the terminal oxidant. Some salient mechanistic features are discussed.

Keywords:

Oxidation, palladium, palladium-catalyzed, carbocycle, heterocycle, synthesis.

Affiliation:

Department of Chemistry and Physics, Arkansas State University, State University, AR



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