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Hypervalent Iodine-Mediated Synthesis of Spiroheterocycles via Oxidative Cyclization

[ Vol. 23 , Issue. 1 ]

Author(s):

Linlin Xing, Yong Zhang and Yunfei Du*   Pages 14 - 37 ( 24 )

Abstract:


Hypervalent iodine reagents have been widely used in the construction of many important building blocks and privileged scaffolds of bioactive natural products. This review article aims to briefly discuss strategies that have used hypervalent iodine reagents as oxidants to synthesize spiroheterocyclic compounds and to stimulate further study for novel syntheses of spiroheterocyclic core structures using hypervalent iodine reagents under metal-free conditions.

Keywords:

Hypervalent iodine reagents, spiroheterocycles, oxidative cyclization, metal-free conditions, dearomatization, cascade annulation.

Affiliation:

Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072

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