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Chemistry and Biological Activity of [1,2,3]-Benzotriazine Derivatives

[ Vol. 22 , Issue. 28 ]

Author(s):

Ghodsi Mohammadi Ziarani*, Manizheh Mostofi and Negar Lashgari   Pages 2717 - 2751 ( 35 )

Abstract:


[1,2,3]-Benzotriazines represent an interesting category of heterocyclic compounds. Various synthetic methods, key reactions and biological aspects have been highlighted. In particular, some analogues have shown antitumor activity. [1,2,3]- Benzotriazin-4-one derivatives are applied extensively as herbicides, insecticides and nematicides. Incorporation of these compounds into the human food chain is a cause of concern, since their toxicity to man is well documented. This review is an attempt to discuss synthesis, chemical reactions, applications and pharmacological aspects of [1,2,3]- benzotriazine analogues from 1957 till date.

Keywords:

[1, 2, 3]- Benzotriazines, [1, 2, 3]- BenzotriazineN-oxide, [1, 2, 3]- Benzotriazin-4(3H)-one, 4- Hydroxy- [1, 2, 3]-benzotriazines, coupling agent, HOOBt.

Affiliation:

Department of Chemistry, Alzahra University, Tehran, P.O. Box 1993893973, Department of Chemistry, Alzahra University, Tehran, P.O. Box 1993893973, Department of Chemistry, Alzahra University, Tehran, P.O. Box 1993893973

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