Submit Manuscript  

Article Details


Titanium Tetrachloride-mediated Synthesis of Diarylmethanes through the Reaction of Benzyl Alcohol Derivatives with Aromatic Substrates

[ Vol. 22 , Issue. 21 ]

Author(s):

Antonella Leggio*, Emilia Lucia Belsito, Alessandra Comandé, Valentina Papaianni and Angelo Liguori*   Pages 2117 - 2123 ( 7 )

Abstract:


Titanium tetrachloride has been successfully used in the benzylation of aromatic substrates with a series of benzyl alcohols under mild reaction conditions. With monosubstituted aromatic substrates, ortho and para-substituted products are obtained in almost comparable amounts. With sterically hindered benzyl alcohol derivatives almost exclusively para-substitution occurs.

Keywords:

Benzyl alcohol, diarylmethanes, friedel crafts reactions, substituted benzyl alcohols, titanium tetrachloride, aromatic substrates.

Affiliation:

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende (CS), Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende (CS), Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende (CS), Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende (CS), Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende (CS)

Graphical Abstract:



Read Full-Text article