Zahra Hosseinzadeh, Ali Ramazani* and Nima Razzaghi-Asl Pages 2256 - 2279 ( 24 )
Cancer is one of the leading causes of death worldwide. Mutation of the cell regulates genes and protein causing cancer. Surgery, radiotherapy, and the use of anticancer agents are the current therapy of cancer despite their side effects. The general area of research relates to heterocyclic chemistry. The purpose of the article is to review the most recent advances in nitrogen-containing heterocyclics as possible chemotherapy agents for cancer. More than 90% of the novel drugs bear heterocyclics and among them, nitrogencontaining heterocyclic compounds show superior pharmaceutical effect than non-nitrogen compounds. Nitrogen-containing compounds, the heart of drug discovery, present a significant and valuable group of molecules that play a chief and vital role in the metabolism of living cells.
Anticancer, heterocyclic, nitrogen-containing heterocyclic, natural nitrogen-containing heterocyclic, synthetic nitrogencontaining heterocyclic, chemotherapy agents.
Department of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan, Department of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan, Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil