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An Efficient Ligandless Palladium-catalyzed Protocol for Suzuki-Miyaura Coupling Reaction of Potassium Aryltrifluoroborates in Water

[ Vol. 22 , Issue. 20 ]

Author(s):

Leifang Liu*, Mingcheng Liu, Jianhua Yang, Baoyong Zhu and Xinfang Wang   Pages 2023 - 2028 ( 6 )

Abstract:


An efficient and ligandless catalytic system was developed for the Suzuki- Miyaura coupling reactions of potassium aryltrifluoroborates in pure water. Using TEAB as additives, Pd(OAc)2 was found to be very efficient for the Suzuki-Miyaura coupling of potassium aryltrifluoroborates with various aryl and heteroaryl bromides in pure water with Na2CO3 as a base, affording the desired products in moderate to excellent yields.

Keywords:

An efficient and ligandless catalytic system was developed for the Suzuki- Miyaura coupling reactions of potassium aryltrifluoroborates in pure water. Using TEAB as additives, Pd(OAc)2 was found to be very efficient for the Suzuki-Miyaura coupling of potassium aryltrifluoroborates with various aryl and heteroaryl bromides in pure water with Na2CO3 as a base, affording the desired products in moderate to excellent yields.

Affiliation:

Key Laboratory of Coordination Chemistry and Functional Materials in Universities of Shandong, Dezhou University, Dezhou 253023, P.R., Key Laboratory of Coordination Chemistry and Functional Materials in Universities of Shandong, Dezhou University, Dezhou 253023, P.R., Chemical Teaching and Research Group, Dezhou No.1 Middle School, Dezhou 253023, P.R., Key Laboratory of Coordination Chemistry and Functional Materials in Universities of Shandong, Dezhou University, Dezhou 253023, P.R., Key Laboratory of Coordination Chemistry and Functional Materials in Universities of Shandong, Dezhou University, Dezhou 253023, P.R.



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