Submit Manuscript  

Article Details


Current Applications of the Sonogashira Reaction in the Synthesis of Heterocyclic Compounds: An Update

[ Vol. 22 , Issue. 14 ]

Author(s):

Majid M. Heravi*, Manizheh Ghanbarian, Nastaran Ghalavand and Niousha Nazari   Pages 1420 - 1457 ( 38 )

Abstract:


The Sonogashira cross-coupling reaction involves the coupling of terminal alkynes with aryl or vinyl halides in the presence of a Pd and a Cu(I) co-catalyst. We tried to reveal the importance of the applications of the Sonogashira reaction in the synthesis of heterocyclic compounds. The reactions occur under relatively mild conditions and tolerate a wide variety of functional groups.

Keywords:

Sonogashira, palladium, Pd-catalyzed, Cu-catalyzed, Cu-free, 2-Formyl/acetyl-N-substituted pyrrolo[2, 3-b]quinoxaline, H-Pyrazolo[5, 1-a]isoquinolines, name reaction.

Affiliation:

Department of Chemistry, Alzahra University, Vanak, Tehran, Department of Chemistry, Alzahra University, Vanak, Tehran, Department of Chemistry, Alzahra University, Vanak, Tehran, Department of Chemistry, Alzahra University, Vanak, Tehran

Graphical Abstract:



Read Full-Text article