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Phenolic Composition, Antioxidant and Cytotoxic Prospective of three Linum species: A Potential Source of Novel Anticancer Pharmacophores

[ Vol. 22 , Issue. 17 ]

Author(s):

Gokhan Zengin*, Carene M.N. Picot, Abdurrahman Aktumsek, Pavle Z. Maskovic, Jelena M. Vujic and Mohamad Fawzi Mahomoodally   Pages 1690 - 1696 ( 7 )

Abstract:


The therapeutic potential of some Linum species has been reported previously. Nonetheless, several species of this genus warrant further scientific consideration. In this study, the phenolic composition, antioxidant activity (DPPH, phosphomolybdenum, iron chelating, hydroxyl radical and lipid peroxidation assays) and cytotoxicity effect (human rhabdomyosarcoma, human cervix carcinoma, and murine fibroblast cell lines) of ethyl acetate, methanol, and water extracts of three Linum species (Linum austriacum subsp. glaucescens, Linum hirsutum subsp. anatolicum, and Linum tenuifolium) were assessed. High performance liquid chromatography with diode-array detection (HPLC-DAD) analysis revealed the presence of ferulic acid, p-hydroxybenzoic acid, synapic acid, rutin, apigenin-glucoside, quercetin, luteolin, and naringenin in all the extracts. It was observed that the extracts (IC50 ranging from 42.07 to 51.66 µg/mL) showed IC50 significantly (p<0.05) lower than ascorbic and gallic acid (> 1000 and 255.43 µg/mL respectively) against lipid peroxidation. According to the American National Cancer Institute guidelines, the extracts showed low cytotoxicity (IC50 < 30 µg/mL). However, the water extracts showed cytotoxicity effects (IC50 17.43±0.13 to 28.12±0.66 µg/mL) against the studied cell lines as compared to the antineoplastic positive control (Cis-DDP). These findings support the use of these plants in the management of ROS mediated disorders and advocates for the need for further scientific evaluations to confirm the observed in vitro bioactivity. The cytotoxic potential coupled with the antioxidant property of the water extracts of these plant species is of particular interest which can open new avenues in the quest for novel anticancer drugs.

Keywords:

Linum, antioxidant, phenolic, nutraceuticals, anticancer, cytotoxic, Turkey.

Affiliation:

Department of Biology, Faculty of Science, Selcuk University, Campus/Konya, Konya, Department of Health Sciences, Faculty of Science, University of Mauritius, Reduit, Department of Biology, Faculty of Science, Selcuk University, Campus/Konya, Konya, Department of Food Technology, Faculty of Agronomy, University of Kragujevac, Cara Dusana 34, 32000 Cacak, Department on Chemistry and Chemical Engineering, Faculty of Agronomy, University of Kragujevac, Cara Dusana 34, 32000 Cacak, Department of Health Sciences, Faculty of Science, University of Mauritius, Reduit

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