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Seven-membered Rings with Three Heteroatoms: Chemistry of 1,2,5- and 1,4,5- thiadiazepines

[ Vol. 22 , Issue. 4 ]


Basak Dogru Mert* and Khaled M. Elattar   Pages 386 - 410 ( 25 )


This review describes the chemistry of 1,2,5- and 1,4,5-thiadiazepines. The investigated heterocycles are monocyclic and fused 1,2,5- and 1,4,5-thiadiazepines. The different sections cover: structural elucidation "spectroscopy", reactivity of substituents attached to ring carbon and nitrogen atoms, synthesis of monocyclic and fused heterocycles incorporated 1,2,5- and 1,4,5-thiadiazepine moiety. Nitrogen and sulfur atoms of thiadiazepine ring system have the ability to donate the electrons pairs in order to form coordination bonds forming different complexes. The aim of this review is to discuss the chemistry of title compounds up till now. The reaction mechanisms are described and discussed, as well as, the biological applications of the target compounds.


1, 2, 5-Thiadiazepines, 1, 4, 5-thiadiazepines, spectroscopic data, reactivity, synthetic methods, biological importance.


Higher School of Health, Mardin Artuklu University, 47200, Mardin, Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura, 35516

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